Table 4.
Molecule ID |
|
kcat s−1 |
KM mM |
kcat/KM M−1 s−1 |
IC50 mM |
---|---|---|---|---|---|
R | |||||
34 | ND | ND | ND | 0.1–0.5 | |
35 | ND | ND | ND | 0.5–1 | |
36 | ∼ 0.3 a | ND | > 300 a | 0.03 |
ND Not determined.
Due to substrate inhibition at higher concentrations, we could only estimate kcat and a kcat/KM (see text and Supporting Information).