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IGFBP-3 KO mice have increased TUNEL labeling of cells in the ganglion cell layer and light staining in outer plexiform layer. TUNEL results for wild-type mice (A–C) and IGFBP3-KO mice (D–F) showing DAPI staining (A, D), and TUNEL labeling (red, B, E) with overlay provided in (C) and (F). Scale bar: 50 μm.
