Figure 6. .

Apoptosis and IGFBP-3 levels in REC treated with a novel β-adrenergic receptor agonist, Compound 49b, or TNF-α. (A) Results from the Cell Death ELISA in REC cultured in normal (5 mM) and high glucose (HG, 25 mM), and treated with Compound 49b (50 nM, 30 minutes) or TNF-α (5 ng/mL; 30 minutes). (B) ELISA results for IGFBP-3 following Compound 49b and TNF-α treatments. *P < 0.05 versus NG no treatment (NT); †P < 0.05 versus HG NT; ‡P < 0.05 versus HG + 49b treatment. N = 3 for all groups.