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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Jun 1;23(15):4441–4446. doi: 10.1016/j.bmcl.2013.05.079

Figure 6. Effects of L-NAME on PEPI-induced changes on citrate synthase activity and mitochondrial protein levels.

Figure 6

CS (A) and porin (B), mitofilin (C), complex I (D), complex II (E) protein densities in BCAEC following exposure for 48 h to either vehicle (control), 0.006 nmol/L PEPI, or 300 μmol/L L-NAME + 0.006 nmol/L PEPI. BCAEC; Bovine coronary artery endothelial cells, CS; citrate synthase activity, PEPI; 3, 3′, 4′, 5, 7-O-penta-acetyl (−)-epicatechin, L-NAME; L-NG-Nitroarginine methyl ester. Values were normalized by arbitrarily setting the densitometry of control levels to 100. Values are mean ± SEM; n=3 per treatment. *p<0.05 vs. control, ψp<0.05 EPI vs. EPI + L-NAME.