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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Trends Biochem Sci. 2013 Jul 10;38(8):394–402. doi: 10.1016/j.tibs.2013.05.005

Figure 1. Menin-interacting proteins and structures of menin with selected interacting proteins.

Figure 1

(A) Four classes of menin interacting proteins based on their cellular functions in context of their interaction with menin: Transcription activators; transcription repressors; cell signaling proteins; and other proteins. Some menin interacting proteins can have dual roles as transcription factors and signaling molecules. (B) The surface representation of menin complexed with MLL1MBM (menin binding motif of MLL1). (C) Overall ternary structure of menin complexed with MLL1MBM-LBM (MLL1 menin binding motif- LEDGF binding motif) and LEDGFIBM.( lens epithelium-derived growth factor integrase binding motif) (D) Crystal structure of menin in complex with JunD peptide. Menin interacts directly with JunD. Menin binding motif of JunD consists of residues 27–47.JunDMBM is shown as purple stick model.(B–D) Reprinted by permission from [40].