. Author manuscript; available in PMC: 2013 Aug 12.

Published in final edited form as: Harv Rev Psychiatry. 2009;17(2):72–86. doi: 10.1080/10673220902899706

TABLE 3.

Differential Responses to SSRIs by Menopausal Status and Gender

Study	Population	n	Agents	Outcome
Raskin et al. (1974)⁹⁸	Women >40 vs. women <40	555 women	Imipramine	Women >40 responded better to imipramine
Kornstein et al. (2000)⁹⁹	Premenopausal women vs. postmenopausal women vs. men	400 women (264 on sertraline, 136 on imipramine); 235 men (162 on sertraline, 73 on imipramine)	Sertraline vs. imipramine	Premenopausal women responded better to sertraline; postmenopausal women and men responded equally to both agents
Baca et al. (2004)¹⁰⁰	Women vs. men	184 women (90 on sertraline, 94 on imipramine); 50 men (23 on sertraline, 27 on imipramine)	Sertraline vs. imipramine	Women responded better to sertraline; men responded equally to both agents
Thase et al. (2005)¹⁰¹	Women >50 vs. women <50 vs. men (meta-analysis of 8 studies)	2045 overall (851 on venlafaxine, 748 on SSRI, 446 on placebo) 1312 women (955 <50, 357 ≥50)	Venlafaxine, SSRI, placebo	Women <50 responded better to SSRI than women >50; no difference for men by age; no difference for venlefaxine by age
Pinto-Meza et al. (2006)¹⁰²	Postmenopausal women vs. premenopausal women	242 women (95 menopausal, 147 premenopausal)	SSRI	Premenopausal women responded better to SSRI

SSRI, selective serotonin reuptake inhibitor.