Table 1. Cosinor analysis of clock genes in the liver.

Gene		r2	p-value	Mesor	p-value	Amplitude	p-value	Acrophase	p-value
Bmal1	Control	0.85	<0.0001	0.54	0.0001	0.55	<0.0001	20.04	0.0793
	Ethanol	0.78	<0.0001	0.37		0.30		19.15
Clock	Control	0.772	<0.0001	0.84	0.0040	0.37	0.0025	21.23	0.6227
	Ethanol	0.31	0.0239	0.70		0.17		20.68
Cry1	Control	0.83	<0.0001	4.03	<0.0001	3.44	<0.0001	17.08	.01090
	Ethanol	0.68	<0.0001	2.17		1.04		15.45
Cry2	Control	0.508	<0.0001	1.73	0.0017	0.65	0.1292	9.82	0.3597
	Ethanol	0.385	0.0062	1.36		0.41		8.78
Dbp	Control	0.695	<0.0001	21.33	0.0447	29.88	0.0099	7.16	0.3335
	Ethanol	0.584	0.0001	14.51		17.35		6.39
Hlf	Control	0.626	<0.0001	19.75	0.0242	18.57	0.0220	11.39	0.1773
	Ethanol	0.714	<0.0001	14.80		11.40		10.44
Nocturnin	Control	0.495	<0.0001	11.34	0.1260	9.74	0.0247	11.04	0.2804
	Ethanol	0.28	0.0392	8.86		4.43		9.61
Npas2	Control	0.696	<0.0001	0.43	0.0601	0.62	0.0110	21.10	0.5140
	Ethanol	0.693	<0.0001	0.31		0.38		20.67
Per1	Control	0.54	<0.0001	17.78	0.0117	16.53	0.0575	9.42	0.3931
	Ethanol	0.59	<0.0001	11.66		10.14		8.66
Per2	Control	0.67	<0.0001	10.10	0.0002	7.10	0.0087	11.96	0.0051
	Ethanol	0.55	0.0002	6.72		3.91		9.58
Rev-erbα	Control	0.752	<0.0001	0.47	0.0248	0.58	0.0048	4.42	0.0419
	Ethanol	0.584	0.0001	0.34		0.33		2.84
Tef	Control	0.69	<0.0001	5.17	0.0524	4.14	0.0268	9.20	0.1677
	Ethanol	0.718	<0.0001	4.31		2.73		8.28