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. 2013 Aug 12;8(8):e71441. doi: 10.1371/journal.pone.0071441

Figure 2. Effect of the adenylyl cyclase activator forskolin on refraction, vitreous chamber depth (VCD), and axial length (AL).

Figure 2

(A) Subconjunctival injection of 10 µM forskolin induced the development of myopia in normal guinea pigs compared to non-injected and vehicle-injected controls at 2 and 4 weeks (**: p<0.01, ***: p<0.001, independent sample t-test). (B) Forskolin also induced an increase in vitreous chamber depth (VCD, *: p<0.05, **: p<0.01), and (C) axial length (AL, **: p<0.01, ***: p<0.001) in normal eyes. (D–F) The 1- and 2-week treatments of subconjunctival forskolin had no effects on FDM eyes. (Normal groups: non-injection n = 16, vehicle n = 12, 10 µM forskolin n = 16; FDM groups: FDM+non-injection n = 12, FDM+vehicle n = 9, FDM+10 µM forskolin n = 11).