Table 2. Frequency and univariate Cox regression analyses of clinical and laboratory characteristics in 227 TB/HIV co-infected patients.
| Variables | N (%) | HR (95%CI) | p-value | |
|---|---|---|---|---|
| Types of TB | ||||
| Smear positive PTB | 92 (40.5) | 1.02 (0.53, 1.97) | 0.944 | |
| Smear negative PTB | 71 (31.3) | 0.94 (0.46, 1.90) | 0.857 | |
| Extrapulmonary TB | 64 (28.2) | 1 | ||
| Status of TB diagnosis | ||||
| Newly diagnosed TB | 161 (70.9) | 0.85 (0.48,1.51) | 0.575 | |
| Ever had TB before | 66 (29.1) | 1 | ||
| Fever | ||||
| Yes | 170 (74.9) | 1.04 (0.56-1.94) | 0.904 | |
| No | 57 (25.1) | 1 | ||
| Cough with sputum | ||||
| Yes | 110 (48.5) | 1.63 (0.94, 2.81) | 0.081 | |
| No | 117 (51.5) | 1 | ||
| Night sweats | ||||
| Yes | 98 (43.2) | 0.64 (0.36, 1.13) | 0.125 | |
| No | 129 (56.8) | 1 | ||
| Changed in TB treatmenta | ||||
| Yes | 37 (16.4) | 0.99 (0.48, 2.03) | 0.982 | |
| No | 190 (83.7) | 1 | ||
| Diabetes Mellitus | ||||
| Yes | 6 (2.6) | 0.44 (0.14, 1.40) | 0.165 | |
| No | 221 (97.4) | 1 | ||
| Number of OIb | ||||
| No OI | 119 (52.4) | 1 | ||
| One OI | 79 (34.8) | 1.86 (1.02, 3.39) | 0.430 | |
| Two OIs | 23 (10.1) | 2.02 (0.85,4.78) | 0.110 | |
| Three or more OIs | 6 (2.6) | 3.72 (1.10,12.52) | 0.340 | |
| Anti-retroviral therapy | ||||
| Yes | 140 (61.7) | 1 | ||
| No | 87 (38.3) | 2.50 (1.45, 4.31) | 0.001 | |
| Hemoglobin level | ||||
| < 12 g/dL | 178 (78.4) | 1.60 (0.75,3.40) | 0.221 | |
| ≥ 12 g/dL | 49 (21.6) | 1 | ||
| Total White Blood Cells | ||||
| (Mean (SD)) | 6.3 (± 3.3) 103/µl | 1.12 (1.05-1.18) | < 0.001 | |
| Serum albumin | ||||
| (Mean (SD)) | 26.5 (± 7.5) g/L | 0.90 (0.86, 0.94) | < 0.001 | |
| CD4 count | ||||
| Not available | 168 (74.0) | 3.95 (0.94, 16.53) | 0.060 | |
| < 200 cells/µl | 39 (17.2) | 3.90 (1.21,12.54) | 0.023 | |
| ≥ 200 cells/µl | 1 | |||
| HbsAg | ||||
| Reactive | 15 (6.6) | 0.82 (0.26-2.63) | 0.737 | |
| Non-reactive/unknown | 212 (93.4) | 1 | ||
| Toxoplasma serology test | ||||
| Reactive | 51 (22.5) | 1.77 (0.99, 3.15) | 0.053 | |
| Non-reactive/unknown | 176 (77.5) | 1 | ||
| Anti-HCV serology | ||||
| Reactive | 127 (55.9) | 1.73 (0.97, 3.08) | 0.062 | |
| Non-reactive/unknown | 89 (39.2) | 1 | ||
aChanged in treatment: change from the initial TB regime (HRZ) to another due to side effects of treatment or adverse reaction.
bOI: Opportunistic infection