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. 2013 Aug 12;8(8):e72050. doi: 10.1371/journal.pone.0072050

Figure 5. Effect of Us3 kinase activity on susceptibility of HSV-1-infected cells to NK cell recognition.

Figure 5

B6MEFs (A) and MHC-I-/-MEFs (B) were infected with HSV-1(F), YK511 (Us3-K220M), or YK513 (Us3-Repair) at an MOI of 1 for 12 h and then co-cultured with NK cells isolated from C57BL/6J mouse splenocytes for an additional 24 h. IFN-γ in the co-culture cell supernatants was quantified by ELISA. Each data point is the mean ± standard error of triplicate samples, and is representative of three independent experiments.