Figure 2. Myocardial substrate uptake and myocardial energy reserve were normal in Pgam2 mice.

(A) Myocardial uptake of ¹⁸F-deoxyglucose (¹⁸FDG) and ¹²⁵I-15-(p-iodophenyl)-9-R,S-methylpentadecanoic acid (¹²⁵I-9MPA) did not differ from that in NTg mice (n = 13 for NTg and n = 18 for Pgam2 mice). SUV: standard uptake value. SUV = tissue concentration (MBq/g)/(injected dose (MBq)/body weight (g)). (B) Cardiac energy reserve was analyzed by measuring cardiac high-energy phosphates with in situ ³¹P magnetic resonance spectroscopy (MRS). ¹H magnetic resonance (MR) imaging was used to define the region of interest to measure the ³¹P MR spectrum of the anterior wall of the left ventricle (lower left panel). Representative in situ cardiac ³¹P MR spectra from NTg and Pgam2 mice are shown (upper panel). ppm: parts per million. The cardiac phosphocreatine (PCr)/βATP ratio of Pgam2 mice at rest did not differ from that of NTg mice (NTg: n = 10; Pgam2 mice: n = 9; lower right panel).