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. 2013 Aug 12;8(8):e70744. doi: 10.1371/journal.pone.0070744

Table 5. Gene Ontological process affected by miRNAs.

Key network objects GO Processes Total nodes Seed nodes p Value zScore gScore
miR 200c, microRNA 200c, miR 20b, miR 31*, c Src phospholipase C activating G protein coupled receptor signaling pathway (21.3%), cell communication (76.6%), signal transduction (72.3%) 50 4 8.96e 08 19.56 19.56
miR 141, microRNA 107, miR 200c, PPAR alpha, ERK1/2 response to endogenous stimulus (58.3%), positive regulation of biological process (77.8%), positive regulation of cellular process (75.0%) 50 3 8.75e 06 14.93 14.93
miR 20b, miR 10b, microRNA 141, p21, Shc developmental process (91.5%), anatomical structure development (87.2%), positive regulation of cellular process (80.9%), positive regulation of biological process (83.0%) 50 3 9.90e 06 14.62 14.62
microRNA 20b, miR 182, microRNA 31, CREB1, Bax cellular response to chemical stimulus (51.1%), cellular response to organic substance (44.4%), response to inorganic substance (31.1%), response to organic substance (53.3%) 50 3 9.90e 06 14.62 14.62
miR 34c 3p, Beta catenin, CDK1 (p34), c Raf 1, GLUT4 positive regulation of cellular process (85.3%), positive regulation of macromolecule metabolic process (70.6%), positive regulation of biological process (85.3%) 38 1 3.07e 02 5.49 5.49
miR 34c 5p, c Myb, Histone H3, Collagen I, PLAU (UPA) response to wounding (63.6%), wound healing (50.0%), coagulation (45.5%), blood coagulation (45.5%), hemostasis (45.5%) 50 1 3.71e 02 4.96 4.96
microRNA 483, FAK1, G protein alpha i family, NF I, eIF4E leukocyte migration (36.7%), hemostasis (44.9%), neuron projection development (46.9%) 50 1 4.02e 02 4.74 4.74