Figure 8. Effects of glial wrapping on mGluR1 receptor responses (model as in Figure 3A, full ADI coverage).

A. Receptor activation (peak value, arbitray units) as a function of distance to release site in control conditions (no glia, blue) and with diffusion barriers but without uptake (glia only, green). B. Changes in perisynaptic receptor response (averaged activation assuming an homogeneous receptor distribution in the non-synaptic part of the ADI) induced by the presence of diffusion barriers (green) and by diffusion barrier with transporters (brown ; 10000/µm²). C. Changes in response kinetic induced by diffusion barriers without transporters (green) and by diffusion barriers with transporters (brown; 10000/µm²).