Table 2. List of the top 20 down -regulated genes in the Pak1 KO MEFs compared to wild-type MEFs.

Refseq	Fold change	Regulation	Gene symbol	Gene description
NM_025949	17.81	down	Rps6ka6	ribosomal protein S6 kinase polypeptide 6
NM_011443	12.38	down	Sox2	SRY-box containing gene 2
NM_008216	11.23	down	Has2	hyaluronan synthase 2
NM_008343	10.79	down	Igfbp3	insulin-like growth factor binding protein 3
NM_012011	9.78	down	Eif2s3y	eukaryotic translation initiation factor 2
NM_134096	9.39	down	Fam19a5	family with sequence similarity 19
NM_009369	9.25	down	Tgfbi	transforming growth factor, beta induced
NM_012008	8.91	down	Ddx3y	DEAD box polypeptide 3,
NM_007539	8.27	down	Bdkrb1	bradykinin receptor, beta 1
NM_026058	7.74	down	Lass4	LAG1 homolog, ceramide synthase 4
NM_009378	7.36	down	Thbd	thrombomodulin
NM_011581	7.19	down	Thbs2	thrombospondin 2
NM_010357	7.18	down	Gsta4	glutathione S-transferase, alpha 4
NM_009484	7.17	down	Uty	ubiquitously transcribed tetratricopeptide
NM_015744	6.96	down	Enpp2	ectonucleotide pyrophosphatase
NM_010308	6.49	down	Gnao1	guanine nucleotide binding protein, alpha O
NM_080288	6.27	down	Elmo1	engulfment and cell motility 1
NM_008973	6.00	down	Ptn	pleiotrophin
NM_175730	5.45	down	Hoxc5	homeobox C5
NM_001037937	5.30	down	Depdc6	DEP domain containing 6