Table 4. List of the top 20 IR responsive genes down regulated by genes in the IR treated Pak1 KO MEFs compared to its IR treated wild-type MEFs.

Refseq	Fold change	Regulation	Gene symbol	Gene description
NM_007539	6.32	down	Bdkrb1	bradykinin receptor, beta 1
NM_028133	3.35	down	Egln3	EGL nine homolog 3 (C. elegans)
NM_021532	3.22	down	Dact1	dapper homolog 1
NM_008970	2.50	down	Pthlh	parathyroid hormone-like peptide
NM_138747	2.42	down	Nop2	NOP2 nucleolar protein homolog (yeast)
NM_010499	2.39	down	Ier2	immediate early response 2
NM_009227	2.38	down	Snrpe	small nuclear ribonucleoprotein E
NM_001011721	2.35	down	Olfr102	olfactory receptor 102
NM_001161845	2.30	down	Sgk1	serum/glucocorticoid regulated kinase 1
NM_008492	2.30	down	Ldhb	lactate dehydrogenase B
NM_019444	2.29	down	Ramp2	receptor (calcitonin) activity modifying protein 2
NM_021878	2.25	down	Jarid2	jumonji, AT rich interactive domain 2
NM_173011	2.24	down	Idh2	isocitrate dehydrogenase 2
NM_007514	2.22	down	Slc7a2	solute carrier family 7, member 2
NM_001012477	2.19	down	Cxcl12	chemokine (C-X-C motif) ligand 12
NM_010898	2.18	down	Nf2	neurofibromatosis 2
NM_178891	2.18	down	Prmt6	protein arginine N-methyltransferase 6
NM_009930	2.17	down	Col3a1	collagen, type III, alpha 1
NM_025392	2.158529	down	Bccip	BRCA2 and CDKN1A interacting protein
NM_029936	2.1434464	down	Ddx10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10