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. 2013 Aug 12;8(8):e71156. doi: 10.1371/journal.pone.0071156

Figure 6. Sustaining proliferation of articular chondrocytes in aged mice by CCN2 overexpression.

Figure 6

(A) PCNA staining in chondrocytes of knee joint cartilage (tibial plateau, frontal sections) of TG joints from 21-month-old mice (a) and of WT joints (b) from 18-month-old mice. a’ and b’: higher magnification of the medial tibial plateau in the load-bearing region indicated by the dotted box in a and b. Bars: 100 µm. In TG articular cartilage, PCNA-positive chondrocytes were observed in the surface area. Bars: 100 µm. (B) PCNA staining of knee joints from 21-month-old littermates and 18-month-old littermates. (C) Left: Percentage of PCNA-positive cells per total cells in TG or WT tibia medial cartilage of individual mice. Right: mean value for TG and WT. TG cartilage showed a significantly higher ratio of PCNA-positive chondrocytes than WT cartilage. *: p<0.001.