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. 2013 Aug 12;8(8):e71184. doi: 10.1371/journal.pone.0071184

Figure 7. Electrical remodeling of Ah-type neurons in adult rats following ovariectomy.

Figure 7

A) Train of somatic action potentials recorded during vagal stimulation at 50 Hz in an Ah-type neuron from a non-ovariectomized rat. The cell responded in a stable 1∶1 fashion to vagal stimulation. There was a progressive decline in the peak amplitude of the evoked action potentials in the train of 50 Hz, concomitant with a positive shift of the take-off potential. Arrowheads denote PEMHs. B) Doubling the vagal stimulation rate was no longer associated with a 1∶1 stimulus/response pattern of the same cell used in (A). C) and D), an Ah-type neuron from an ovariectomized rat failed to respond to vagal stimulation in a 1∶1 ratio at stimulation frequencies ≥50 Hz. E) Plots of incidence of evoked somatic action potentials as a function of vagal stimulation frequency in Ah-type VGNs isolated from non-ovariectomized and ovariectomized rats. Data are mean ±1 SD (n = 6) with **P<0.01 vs non-ovariectomized. Scale bar in (A) & (B) apply to all panels.