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. 2013 Aug 12;8(8):e71076. doi: 10.1371/journal.pone.0071076

Figure 7. The LV-GDNF gradient does not increase the total number of motoneurons that reach the distal nerve.

Figure 7

Regenerated motoneurons were retrogradely traced at the the mid-thigh level (corresponding to segment 6 in Figure 1), 16 weeks after lesion. A) Non-lesioned motoneuron pool stained for ChAT (red), demonstrating normal motoneuron morphology (arrowheads). B) Lesioned motoneuron pool containing retrogradely labeled neurons (blue, open arrowheads) and non-traced motoneurons (closed arrowheads). C) Left panel: the number of in the number of retrogradely labeled (i.e., regenerated) motoneurons does not differ between LV-GArGFP and LV-GDNF groups. Right panel: the number of visible motoneurons is approximately 50% of the contralateral side in both groups (right panel). Scale bar in B: 100 µm.