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. 2013 Aug 12;8(8):e71211. doi: 10.1371/journal.pone.0071211

Table 1. Base excision repair pathway genes investigated.

Gene Symbol # tagSNPs Chromosomal location Protein Function
APEX1 13 14q11.2 Endonuclease
FEN1 7 11q12 Endonuclease
LIG1 23 19q13.2-q13.3 Ligase
LIG3 7 17q11.2-q12 Ligase
MUTYH 7 1p34.1 Glycosylase
NEIL1 4 15q33.33 Glycosylase
NEIL2 43 8p23.1 Glycosylase
NTHL1 9 16p13.3 Endonuclease and Glycosylase
OGG1 7 3p26 Glycosylase
PARP1 18 1q41-q42 poly(ADP-ribosyl)ation
POLβ 6 8p12-p11 Polymerase
POLD1 7 19q13.3 Polymerase
SMUG1 10 12q13.11–13.3 Glycosylase
XRCC1 21 19q13.2 Scaffolding protein

Genes are listed according to HUGO gene nomenclature format (http://www.genenames.org), Abbreviations: APEX1, APEX nuclease 1; FEN1, flap structure-specific endonuclease 1; LIG1, ligase I, DNA, ATP-dependent; LIG3, ligase III, DNA, ATP-dependent; MUTYH, mutY homolog (E. coli); NEIL1, nei endonuclease VIII-like 1 (E. coli); NEIL2, nei endonuclease VIII-like 2 (E. coli); NTHL1, nth endonuclease III-like 1 (E. coli); OGG1, 8-oxoguanine DNA glycosylase; PARP, poly (ADP-ribose) polymerase 1; POLβ, polymerase (DNA directed),beta; POLD1, polymerase (DNA directed), delta 1, catalytic subunit 125 kDa; SMUG1, single-strand-selective monofunctional uracil-DNA glycosylase 1; XRCC1, X-ray repair complementing defective repair in Chinese hamster cells 1.