Table 3. Colorectal adenoma SNP associations among the entire population and stratified by race/ethnicity.

Gene	SNP	All combined	Non-Hispanic White	African-American	Hispanic	Asian-Pacific Islander	Phet e
NEIL2	rs11785481						0.131
	Ca/Coa	666/692	354/364	121/109	116/140	75/79
	OR b	0.70	0.64	0.60	1.29	0.25
	95%CI	0.55–0.90	0.48–0.87	0.24–1.53	0.72–2.31	0.05–1.37
	pc	0.006	0.004	0.286	0.387	0.111
	pACT d	0.139	0.089	1.000	1.000	0.806
FEN1	rs108499						0.024
	Ca/Coa	691/663	353/365	122/109	113/140	75/77
	OR b	1.06	0.95	0.67	1.09	2.12
	95%CI	0.90–1.25	0.76–1.18	0.37–1.21	0.76–1.57	1.30–3.45
	pc	0.516	0.635	0.185	0.641	0.002
	pACT d	1.000	1.000	0.645	1.000	0.009
APEX1	rs17111750						0.004
	Ca/Coa	695/664	354/367	121/110	114/140	75/78
	OR b	1.00	0.88	2.19	0.78	1.04
	95%CI	0.85–1.18	0.71–1.10	1.36–3.55	0.52–1.15	0.58–1.86
	pc	0.981	0.271	0.001	0.208	0.897
	pACT d	1.000	0.781	0.013	0.573	1.000
FEN1	rs509360	697/665					0.052
	Ca/Coa	697/665	353/367	122/111	116/140	74/79
	OR b	0.93	0.95	1.27	1.09	0.49
	95%CI	0.78–1.09	0.76–1.19	0.81–2.01	0.71–1.68	0.30–0.79
	pc	0.358	0.662	0.302	0.694	0.003
	pACT d	0.888	1.000	0.746	1.000	0.011
NTHL1	rs2516781						0.062
	Ca/Coa	688/664	353/363	122/108	115/140	74/77
	OR b	0.91	1.01	0.83	1.06	0.45
	95%CI	0.77–1.08	0.80–1.27	0.51–1.34	0.74–1.52	0.25–0.80
	pc	0.271	0.960	0.445	0.747	0.006
	pACT d	0.840	1.000	0.960	1.000	0.033

^aExcludes 21 individuals who characterized their race/ethnic group as "other";

^bPer-allele ORs and 95%confidence intervals computed using logistic regression assuming a log-additive model and adjusting for age, exam date, sex, clinic, study phase and race among all study participants;

^cCrude p-value;

^dCrude p-value corrected for multiple comparisons using P_ACT;

^eRace/ethnicity specific per-allele ORs and 95% confidence intervals computed using logistic regression assuming a log-additive model and adjusting for the matching factors age, exam date, sex, clinic, study phase; ^e p-value for heterogeneity by race.