Table 4. Significant BER per-allele associations by polyp sub-site.

		Rectal Polyp						Colon Polyp						Rectal/Colon
Gene	SNP	CA/COa	ORb	95%CI	Pc	PACT d	P pathway e	CA/COa	ORb	95%CI	Pc	PACT d	P pathway e	phet f
NEIL2	rs3757949	123/669	1.58	1.18–2.13	0.002	0.044	0.610	528/669	1.02	0.85–1.23	0.795	1.000	1.000	0.004
NEIL2	rs7015453	123/670	1.72	1.24–2.39	0.001	0.025	0.346	525/670	1.03	0.84–1.27	0.738	1.000	1.000	0.003

^aExcludes 21 individuals who characterized their race/ethnic group as "other.";

^bPer-allele ORs and 95%confidence intervals computed using multinomial logistic regression assuming a log-additive model and adjusting for age, exam date, sex, clinic, study phase, and race among all study participants;

^cCrude p-value;

^dCrude p-value corrected for multiple comparisons using P_ACT;

^ePathway wide (p_pathway) p-value based on Bonferroni correction of P_ACT for the number of BER gene regions investigated (N = 14);

^fp-value for heterogeneity by polyp subsite.