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. 2013 Aug 12;8(8):e71211. doi: 10.1371/journal.pone.0071211

Table 5. Smoking, alcohol, dietary folate and adenoma risk by genotype among all subjects.

Exposure variable CA/CO CA/CO CA/CO OR a,b,c 95%CI P OR a,b,c 95%CI P OR a,b,c 95%CI P
LIG3 rs105236
Alcohol Intake CC CT TT C/C C/T T/T
Never 97/108 99/106 34/30 1ref 1ref 1ref
≤6 g/day 67/81 73/76 31/38 1.05 0.70–1.58 0.818 0.90 0.67–1.22 0.499 0.77 0.44–1.35 0.369
>6 g/day 89/61 99/99 23/38 1.77 1.17–2.68 0.006 1.01 0.75–1.36 0.962 0.57 0.32–1.01 0.053
p trend 0.003 0.719 0.071
interaction pd = 0.005; interaction pgene e = 0.019; interaction ppathway f = 0.241
Alcoholic Drinks CC CT TT C/C C/T T/T
Never 97/108 99/106 34/30 1ref 1ref 1ref
≤1 drink/day 112/116 121/117 41/56 1.24 0.86–1.80 0.247 0.96 0.73–1.26 0.752 0.74 0.44–1.23 0.243
>1 drink/day 44/26 51/58 13/20 1.84 1.09–3.11 0.022 0.97 0.67–1.38 0.848 0.51 0.25–1.01 0.052
p trend 0.024 0.807 0.048
interaction pd = 0.010; interaction pgene e = 0.029; interaction ppathway f = 0.345
Folate mcg/day CC CT TT C/C C/T T/T
≤267 106/101 110/92 36/26 1ref 1ref 1ref
>267–387 65/85 84/89 31/38 0.77 0.52–1.15 0.205 0.74 0.55–0.99 0.040 0.70 0.40–1.23 0.215
≥388 82/64 77/100 21/42 1.29 0.86–1.93 0.212 0.69 0.51–0.93 0.015 0.37 0.20–0.65 0.001
p trend 0.175 0.021 <0.001
interaction pd = 0.001; interaction pgene e = 0.006; interaction ppathway f = 0.081
LIG3 rs3744358
Folate mcg/day TT TG GG T/T T/G G/G
≤267 139/128 91/79 22/12 1ref 1ref 1ref
>267–387 81/117 74/74 26/19 0.66 0.46–0.94 0.022 0.83 0.59–1.16 0.269 1.05 0.54–2.04 0.890
≥388 103/100 65/80 11/26 1.07 0.75–1.53 0.719 0.63 0.45–0.90 0.010 0.38 0.19–0.75 0.006
p trend 0.577 0.010 0.003
interaction pd = 0.008; interaction pgene e = 0.032; interaction ppathway f = 0.451
MUTYH rs10890324
Smoking Pack-yrs AA AG GG A/A A/G G/G
Never 116/132 89/108 25/32 1ref 1ref 1ref
>0–21 75/86 59/74 20/24 0.98 0.67–1.45 0.928 0.99 0.72–1.36 0.950 1.00 0.54–1.86 0.993
>21 95/99 89/64 44/18 1.02 0.70–1.49 0.903 1.76 1.29–2.42 <0.001 3.03 1.67–5.51 <0.001
p trend 0.871 <0.001 <0.001
interaction pd = 0.002; interaction pgene e = 0.007; interaction ppathway f = 0.091
OGG1 rs159153
Smoking Pack-yrs TT TC CC T/T T/C C/C
Never 116/139 96/106 18/27 1ref 1ref 1ref
>0–21 86/91 52/75 15/16 1.06 0.73–1.55 0.746 0.95 0.67–1.33 0.747 0.84 0.42–1.66 0.615
>21 94/96 109/73 24/12 1.11 0.76–1.62 0.578 1.75 1.26–2.44 0.001 2.76 1.43–5.31 0.002
p trend 0.610 <0.001 <0.001
interaction pd = 0.013; interaction pgene e = 0.040; interaction ppathway f = 0.517
FEN1 rs108499
Smoking Pack-yrs CC CT TT C/C C/T T/T
Never 95/118 87/108 48/44 1ref 1ref 1ref
>0–21 64/70 56/86 32/27 1.02 0.67–1.54 0.926 0.96 0.71–1.29 0.771 0.90 0.52–1.56 0.7
>21 124/79 82/78 21/22 1.99 1.36–2.91 <0.001 1.25 0.92–1.71 0.156 0.79 0.44–1.41 0.424
p trend <0.001 0.102 0.446
interaction pd = 0.013; interaction pgene e = 0.039; interaction ppathway f = 0.507
a

Odds ratios (ORs) are from models with genotype coded as log-additive (treated as continuous) and adjusted for age, sex, clinic, exam date, study phase, and race among all study participants. Excludes 21 individuals who characterized their race/ethnic group as "other";

b

ORs for smoking additionally adjusted for alcohol intake (g/d) and dietary folate intake (mcg/day); ORs for alcohol additionally adjusted for smoking pack-years and dietary folate intake (mcg/d); ORs for dietary folate intake, additionally adjusted for alcohol intake (g/d) and smoking pack-years;

c

ORs derived from a common baseline model that included the SNP, smoking, alcohol, dietary folate exposure and interaction terms between genotype and smoking, alcohol, dietary folate exposure levels;

d

Crude interaction p-value;

e

Within gene region, Bonferroni adjusted interaction p-value, based on the number of SNPs within the respective gene region;

f

Pathway wide, Bonferroni adjusted interaction p-value, based on 14 investigated BER gene regions.