Table 1.
Cases | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
---|---|---|---|---|---|---|---|---|---|
Age (years) | 31.4 | 29.5 | 58.5 | 31.7 | 39.9 | 34.9 | 3.7 | 4.7 | 1.8 |
Sex | Female | Female | Male | Male | Female | Male | Male | Male | Female |
Leptospirosis confirmed or probable | Probable | Probable | Probable | Confirmed | Confirmed | Confirmed | Confirmed | Confirmed | Confirmed |
Prior HIV test positivea | Yes | No | No | Yes | No | Yes | Yes | Yes | Yes |
CD4 (cells/μL) | 1105 | 203 | None | 86 | 98 | 484 | 313 | 1014 | 357 |
CD4 % | 45 | 18 | None | 11 | 11 | 37 | 26 | 22 | 4 |
Prescribed ART | Yes | No | No | Yes | No | Yes | Yes | Yes | Unknown |
Prescribed SXT prophylaxisb | Yes | No | No | Yes | No | Yes | — | — | — |
Died | No | Yes | Yes | No | No | No | No | No | No |
Admitting diagnoses | Malaria | Meningitis, cerebral malaria | Urinary tract infection, malaria | Tuberculosis, malaria | Malaria | HIV, malaria | Pneumonia, otitis media | HIV/AIDS, pneumonia | HIV/AIDS, marasmus, malaria |
Discharge diagnosesb | HIV, malaria | Meningitis | Severe malaria | Malaria | HIV, malaria | HIV, malaria | — | — | — |
Concurrent infections | None | S. pneumoniae bacteremia | E. coli bacteremia | None | Salmonella Typhi bacteremia | None | S. pneumoniae bacteremia | None | None |
Antibacterials during admission | None | Penicillin, chloramphenicol | Penicillin | None | SXT metronidazole | None | Ampicillin, gentamicin | Ampicillin, gentamicin | Ampicillin, gentamicin |
Leptospirosis predominant serogroupc | Mini | Canicola | Mini | Celledoni | Australis | Australis | Ictero-hemorrhagiae, Mini | Mini | Ictero-hemorrhagiae, Mini |
Highest MAT reciprocal titer | 1600 | 1600 | 800 | 800 | 400 | 400 | 200 | 200 | 200 |
Known to be HIV infected prior to study enrollment.
Data not collected for infants and children.
Defined as the serogroup for the reacting serovar with the highest MAT titer.
HIV, human immunodeficiency virus; ART, antiretroviral therapy; SXT, trimethoprim-sulfamethoxazole; MAT, microscopic agglutination test.