Table 1. Tumors from multiparous and nulliparous Casp2−/−/MMTV animals display abnormal multinucleated cells with bizarre mitoses and karyomegaly.
| Mild KM | Rare MN | KM with slight MN | KM with moderate MN | Abnormal KM with MN and bizarre mitoses | Necrotic | |
|---|---|---|---|---|---|---|
| A | ||||||
| Casp2+/+ | 60.0 | 10.0 | 10.0 | 20.0 | 0.0 | 0.0 |
| Casp2 +/− | 45.5 | 18.2 | 27.3 | 0.0 | 0.0 | 9.1 |
| Casp2 −/− | 5.0 | 5.0 | 5.0 | 10.0 | 75.0 | 0.0 |
| B | ||||||
| Casp2+/+ | 45.5 | 0.0 | 45.5 | 9.1 | 0.0 | 0.0 |
| Casp2 +/− | 63.6 | 9.1 | 18.2 | 0.0 | 0.0 | 0.0 |
| Casp2 −/− | 25.0 | 0.0 | 25.0 | 0.0 | 50.0 | 0.0 |
The morphology of tumors isolated from multiparous (A) and nulliparous (B) Casp2+/+/MMTV (n=10 multiparous, n=11 nulliparous), Casp2+/−/MMTV (n=11 multiparous, n=11 nulliparous) and Casp2−/−/MMTV (n=20 multiparous, n=8 nulliparous) animals were examined by H&E staining and classified into one of six morphological categories (see text). The frequency of each morphological type is noted. Images of selected morphologies are shown in Figure 2. P-values for all groups were <0.001 as determined by χ2 test.