Figure 7.

Intrinsic disorder (plots a, c, and e) and STRING analysis (plots b, d, and f) of the interactomes of some proteins involved in the p53-mediated apoptotic signaling pathway. (a and b) Mdm2 (UniProt ID: Q00987); (c and d) p53 (UniProt ID: P04637); (e and f) PUMA (UniProt ID: Q96PG8). Intrinsic disorder propensity was evaluated by PONDR FIT (red curves). Shadow around PONDR FIT curves represents distribution of statistical errors. STRING database is the online database resource Search Tool for the Retrieval of Interacting Genes, which provides both experimental and predicted interaction information.³⁹ For each protein, STRING produces the network of predicted associations for a particular group of proteins. The network nodes are proteins. The edges represent the functional associations evaluated based on the experiments, search of databases and text mining. The thickness of edges is proportional to the confidence level³⁹