Table 4.
Commercial SPIO.
| Company | Brandb | Size (nm)a | Coating |
|---|---|---|---|
| I) SPIO approved by FDA or under clinical trials from pharmaceutical companies | |||
| Guerbet, AMAG Pharm, Inc |
Ferumoxidesd AMI-25 Feridex/Endorem |
120-180 | Dextran T10 |
| Ferumoxtran-10 AMI-227 Combidex/Sinerem |
15-30 | Dextran T10, T1 | |
| Bayer Schering Pharma AG | Ferucarbotran SHU 555A Resovist |
60 | Carboxydextran |
| SHU 555C Supravist |
21 | carboxydextran | |
| Ferumoxytol Code 7228 |
30 | Polyglucose sorbitol carboxymethyl ether | |
| GE-healthcare | Feruglose NC-100150 Clariscan |
20 | Pegylated Starch |
| Ferropharm | VSOP-C184 | 7 | Citrate |
| II) SPIO products from different chemical companies | |||
| Sigma-Aldrich | Superparamagnetic iron oxide nanoparticles | 5nm, 10nmc | 1.0% modified short chain polyethylene glycol (PEG) |
| Oceannanotech | IDX | 5-10 | Dextran |
| ILP | 10, 20, 30 | lipid | |
| ILA | 10, 20, 30 | Lipid with terminal amine groups | |
| SMG | 10, 20, 30 | Amphiphilic polymer, PEG | |
| SHQ | 10 | Amphiphilic polymer, polydiallydimethylammounium chloride (PDDA) | |
| SEI | 10, 15, 20, 25, 30 | Amphiphilic polymer, polyethylenimine (PEI) | |
| SHP | 5, 10, 15, 20, 25, 30 | Amphiphilic polymer with carboxylic acid groups | |
| SHA | 10, 15, 20, 25, 30 | Amphiphilic polymer with amine groups, PEG | |
| SXP | 5, 10, 15, 20, 25, 30 , 40 | Amphiphilic polymer with carboxylic acid groups, endotoxin free |
|
| Nanocomposix | Magnetite nanoparticle | 5.4nm | Tetramethyl amine |
| NN-Labs, LLC | Magnetic iron oxide nanocrystals in water | 5, 10, 20 | |
| TurboBeads | TurboBeads Amine | 30 | Primary aliphatic amine groups |
| Turbobeads Carboxyl | 30 | Carboxyl groups | |
| Sciventions | Magnetite | 1-10 | Polyacrylate sodium |
| Chemicell | fluidMAG-ARA | 50,75, 100, 150, 200 | Glucuronic Acid |
| fluidMAG-Chitosan | 50,75, 100, 150, 200 | Chitosan | |
| fluidMAG-CMX | 50,75, 100, 150, 200 | Carboxylmethyldextran | |
| fluidMAG-D | 50,75, 100, 150, 200 | Starch | |
| fluidMAG-DEAE | 50,75, 100, 150, 200 | DEAE-starch | |
| fluidMAG-DX | 50,75, 100, 150, 200 | Dextran | |
| fluidMAG-DXS | 50,75, 100, 150, 200 | Dextran-sulfate | |
| BioPAL | Molday ION™ | 35 | Rhodamine, C6amine, |
a. Hydrodynamic size. b. all used brandnames of the same compound are listed. c. TEM size. d. Feridex® was discontinued byGuerbet, AMAG Pharm, Inc in 2009 because it competed with other MRI contrast agents sold by Guerbet, AMAG Pharm, Inc.