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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Crit Rev Immunol. 2013;33(3):203–218. doi: 10.1615/critrevimmunol.2013007409

Table 2.

Evidence of a functional role for KIR3DS1

Condition Genotype Finding Ref
HIV 3DS1+Bw4 80l Delayed progression towards AIDS 47
3DS1+Bw4 80l Protection from opportunistic infections 60
3DS1 homozygous Reduced risk of acquisition of infection in HIV exposed individuals 61
3DS1+ Bw4 Increased in HIV exposed seronegative 62
3DS1+Bw4+3DL1 Increased KIR3DS1 gene copy number associated with lower viral set point. 53
HBV 3DS1 Associated with spontaneous recovery 63
HCV 3DS1 homozygous + Bw4 Increased risk of cirrhosis 64
3DS1+Bw4 80l Decreased risk of hepatocellular carcinoma 65
Tuberculosis 3DS1+Bw4 80l Decreased susceptibility 66
Cervical neoplasia 3DS1+ Bw4 Increased risk 67
Multiple Myeloma 3DS1 Decreased progression-free survival after autologous stem cell transplantation 68
Endometriosis 3DS1 Reduced susceptibility 69
Ankylosing Spondylitis 3DS1 Increased susceptibility 70,71
3DS1 No effect 72
3DS1+Bw4 80l Increased susceptibility 73
HSCT 3DS1 (donor) Decreased acute GvHD 74
Functional
HIV Increased inhibition of viral production by 3DS1+ NK cells in Bw4 80I patients. Preferential activation of KIR3DS1+ cells upon exposure to HIV+ Bw4 80I+ cells 51
Expansion of KIR3DS1+ NK cells in acute HIV infection 52
Increased IFN-γ production and CD107a levels in 3DS1+ donors at baseline and after stimulation with class I negative target cells. Not associated with Bw4 80I 75