Table 3a.
Odds ratio (95% CI) of CHD associated with RBP4 levels during the first 8 years of follow-up, the Nurses’ Health Study
| Quartiles of RBP4 levels (μg/mL) | Ptrend | ||||
|---|---|---|---|---|---|
|
| |||||
| 1 (lowest) | 2 | 3 | 4 (highest) | ||
| Full-length RBP4 | |||||
| Median (range) | 37.7 (22.1–47.9) | 55.5 (48.0–62.4) | 72.9 (62.5–85.9) | 106.3 (86.9–217.5) | |
| Case/control | 40/48 | 29/43 | 55/54 | 65/43 | |
| Model 1* | 1.0 | 0.96 (0.48, 1.93) | 1.72 (0.83, 3.56) | 2.92 (1.34, 6.38) | 0.002 |
| Model 2† | 1.0 | 0.70 (0.28, 1.72) | 1.58 (0.61, 4.09) | 3.56 (1.21, 10.51) | 0.003 |
| Model 3‡ | 1.0 | 0.62 (0.19, 2.01) | 1.76 (0.52, 5.98) | 4.45 (1.07, 18.51) | 0.007 |
| RBP4-L | |||||
| Median (range) | 14.3 (5.5–18.1) | 21.3 (18.2–24.9) | 30.4 (25.0–35.6) | 47.0 (36.2–148.0) | |
| Case/control | 43/49 | 35/49 | 58/41 | 53/49 | |
| Model 1* | 1.0 | 0.99 (0.52, 1.88) | 1.94 (0.96, 3.94) | 1.58 (0.79, 3.17) | 0.18 |
| Model 2† | 1.0 | 0.72 (0.31, 1.65) | 1.08 (0.42, 2.76) | 1.29 (0.50, 3.32) | 0.33 |
| Model 3‡ | 1.0 | 0.57 (0.18, 1.82) | 1.40 (0.38, 5.18) | 1.30 (0.33, 5.19) | 0.34 |
| Total RBP4 | |||||
| Median (range) | 54.9 (28.5–67.5) | 79.6 (67.6–88.7) | 107.1 (89.6–126.0) | 158.2 (126.1–350.2) | |
| Case/control | 37/51 | 34/46 | 55/45 | 63/46 | |
| Model 1* | 1.0 | 1.41 (0.70, 2.83) | 2.58 (1.21, 5.50) | 3.21 (1.47, 7.02) | 0.003 |
| Model 2† | 1.0 | 0.95 (0.39, 2.32) | 2.08 (0.78, 5.57) | 3.88 (1.34, 11.21) | 0.003 |
| Model 3‡ | 1.0 | 0.96 (0.30, 3.09) | 2.56 (0.71, 9.22) | 6.62 (1.55, 28.34) | 0.003 |
Model 1 was adjusted for the matching factors: age at blood draw, smoking status (never, past, current), fasting status (yes, no), and time of blood drawing.
Based on model 1, model 2 was further adjusted for body mass index (kg/m2), menopausal status (yes, no), hormone use (current user, past user, and non-user), physical activity (MET-hrs/week), alcohol use (g/day), parental history of MI before age 65 years (yes, no), use of aspirin (yes, no), glomerular filtration rate, intakes of whole grains, trans fat, and polyunsaturated fat (in tertiles), and history of hypercholesterolemia, diabetes, or hypertension (yes, no).
Based on model 2, model 3 was further adjusted for total cholesterol (mg/dL), triacylglycerol levels (mg/dL), high-sensitivity C-reactive protein (mg/L), hemoglobin A1c (%), and total adiponectin (μg/mL).