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. Author manuscript; available in PMC: 2013 Aug 13.
Published in final edited form as: Nature. 2011 Feb 9;470(7334):359–365. doi: 10.1038/nature09787

Figure 3. Telomere dysfunction induces cardiomyopathy, defective gluconeogenesis and reduced HSC reconstitution capacity.

Figure 3

Telomerase and PGC-1α overexpression improves gluconeogenesis and mitochondrial respiration in G4 mice. a, Decreased fractional shortening (FS %) in 15-monthold G4 mice and signs of end-stage cardiomyopathy (left ventricular diameter (LVD) increase and thinning of left ventricular wall (LVW), n = 5–8 per genotype). b, Glucose levels in mice under fed and starved conditions (n = 10 per genotype). c, Long-term repopulation capacity in competitive transplants was determined using CD45.1- and CD45.2-specific antibodies. Shown is the percentage contribution of donors after 4 months. (n = 8 donors per group, three recipients per donor). d, Overexpression of Tert by adenovirus attenuates gluconeogenesis defect in G4 mice (n = 8 per group). e, Overexpression of PGC-1α attenuates gluconeogenesis defect in G4 mice. (n = 8–10 per group). f, PGC-1α overexpression rescues respiration defect (complex I) in G4 liver mitochondria (n = 5 per group). Student t-test was used to calculate the statistical differences in all assays described and error bars represent s.e.m.