Table 2. Demographic, Laboratory, Ultrasound Features of the First Group of Patients Stratified by Presence or Absence of Histological Cirrhosis (n = 249)b.
| Patients without cirrhosis (n = 198) | Patients with cirrhosis (n = 51) | P value | |
|---|---|---|---|
| Age, y, No (Median) | 46 (33-54) | 52 (45-56) | < 0.001 |
| Sex, % | 0.037 | ||
| Male | 58.6 | 74.5 | |
| Female | 41.4 | 25.5 | |
| Alcohol consumption, % | 13.4 | 17.5 | 0.500 |
| Pervious Antiviral treatment, % | 11.6 | 19.6 | 0.133 |
| Splenomegaly at ultrasound, % | 22 | 36.2 | 0.045 |
| Iron, µg/mL | 114 (83-143) | 151 (112-183) | < 0.001 |
| Glucose, mg/ dL | 88 (79-99) | 93 (86-109) | 0.002 |
| Total Bilirubin, mg/ dL | 0.61 (0.48-0.80) | 0.73 (0.59-1.04) | 0.002 |
| ASTa, U/L | 56 (39-83) | 94 (64-119) | < 0.001 |
| ALTa, U/L | 93 (54-159) | 139 (83-198) | 0.001 |
| Alkaline phosphatase , U/L | 147 (95-205) | 219.5 (130-296) | 0.001 |
| Albumin, g/ dL | 4.4 (4.2-4.6) | 4.3 (4.1-4.5) | 0.020 |
| Cholinesterase,U/L | 11,062 (8,799-12,996) | 8,949 (6,892-11,270) | 0.001 |
| White blood cells,cells/ μL | 6,450 (5,300-7,800) | 6,400 (5,500-7,300) | 0.541 |
| Red blood cells,cells/ μL | 4,860,000 (4,630,000-5,190,000) | 4,910,000 (4,570,000-5,190,000) | 0.765 |
| Platelets, elements/μL | 198,500 (171,750-245,000) | 149,500 (118,000-188,000) | < 0.001 |
| Hemoglobin,g/dL | 15.0 (14.1-15.9) | 15.4 (14.7-16.1) | 0.044 |
| Prothrombin activity, % | 101 (93-108) | 92 (86-99) | < 0.001 |
| Alpha-fetoprotein,pg/mL | 3.3 (2.2-5.8) | 8.1 (3.9-17.2) | < 0.001 |
| Ferritin, ng/mL | 137 (61-234) | 195 (130-445) | 0.037 |
| HCVaRNA, UI/mL | 511,000 (200,000–850,000) | 698,000 (126,500–980,000) | 0.541 |
aAbbreviations: ALT, Alanine Aminotransferase; AST, Aspartate Aminotransferase; HCV, hepatitis C virus
bData were compared using χ 2 test for categorical variables and Mann-Whitney U test for quantitative variables