Table 1. Baseline characteristics of 179 patients accepted for isolated TA-TAVI between 2005-2012 at St. Paul’s Hospital in Vancouver, Canada.
| Parameter | Overall (n=178) | Early cohort (n=89) | Late cohort (n=89) | P value |
|---|---|---|---|---|
| Age | 80.5 (8.6) | 80.5 (8.0) | 80.5 (9.2) | 1.00 |
| Female | 99 (55.3) | 56 (62.9) | 43 (47.8) | 0.12 |
| Body mass index (kg/m2) | 25.0 (4.8) | 24.7 (4.3) | 25.3 (5.3) | 1.00 |
| Diabetes | 53 (29.8) | 22 (25.3) | 31 (34.4) | 0.37 |
| Dyslipidemia | 129 (72.1) | 66 (75.0) | 63 (70.0) | 1.00 |
| Hypertension | 147 (82.1) | 71 (80.7) | 76 (84.4) | 0.77 |
| Smoking | 96 (53.6) | 50 (56.8) | 46 (51.1) | 1.00 |
| Congestive heart failure | 136 (76.4) | 54 (62.1) | 82 (91.1) | <0.0001 |
| Pulmonary hypertension | 54 (30.5) | 25 (29.1) | 29 (32.6) | 1.00 |
| Cerebrovascular accident | 40 (22.9) | 20 (23.8) | 37 (41.6) | 0.03 |
| Pulmonary disease | 49 (27.4) | 20 (22.7) | 29 (32.6) | 0.31 |
| Dialysis | 5 (2.9) | 1 (1.2) | 4 (4.4) | 0.40 |
| Peripheral vascular disease | 103 (59.2) | 56 (67.5) | 47 (52.2) | 0.12 |
| Coronary artery disease | 141 (78.8) | 71 (80.7) | 70(77.8) | 1.00 |
| Previous myocardial infarction | 87 (48.6) | 57 (64.8) | 30 (33.3) | <0.0001 |
| Previous cardiac surgery | 79 (44.4) | 43 (49.4) | 36 (40.0) | 0.41 |
| Previous percutaneous coronary intervention | 41 (22.9) | 18 (20.5) | 23 (25.6) | 0.84 |
| Porcelain aorta | 39 (22.7) | 21 (25.9) | 18 (20.5) | 0.80 |
| Atrial fibrillation/Flutter | 62 (35.6) | 33 (39.8) | 29 (32.2) | 0.60 |
| Permanent pacemaker | 37 (21.0) | 20 (23.5) | 17 (19.1) | 0.95 |
| Renal failure | 60 (33.9) | 20 (23.3) | 40 (44.4) | 0.004 |
| Creatinine (μmol/L) | 122.5 (92.0) | 110.8 (62.7) | 135.0 (115.4) | 0.33 |
| GFR (mL/min) | 55.2 (22.6) | 56.9 (23.1) | 53.5 (22.0) | 1.00 |
| Hgb (mmol/L) | 120.6 (18.2) | 120.6 (16.0) | 119.4 (20.4) | 1.00 |
| Society of thoracic surgery risk score (%) | 10.3 (6.6) | 11.4 (7.1) | 9.0 (5.6) | 1.00 |
Parameters presented as mean (standard deviation) for continuous variables and number (percentage) for categorical variables. Early cohort – first 89 patients undergoing TA-TAVI; late cohort - next 90 patients undergoing TA-TAVI. P-value, comparing baseline characteristics between early and late cohort, calculated using the Z-test for continuous variables and two-tailed chi square test for categorical variables