Table 1. Clinical prognostic studies.
| Marker | Year | Author | N | Data: univariate predictors | Multivariate |
|---|---|---|---|---|---|
| Lab/Clinical: Japan | 2011 | Nojiri (6) | 314 | Demographic and laboratory parameters | Age >70, non-epithelial, low PS, high WBC, high CRP |
| Lab/Clinical: Turkey | 2010 | Tanrikulu (7) | 363 | Glucose <40, CRP >50: ↓survival | KPS, serum LDH, presence of pleural effusion, pleural thickening >1 cm, and PLT >420k |
| Clinical | 2010 | Richards (8) | 354 | Stratification of T and N status, epithelial only |
N2b vs. N2a nodal status with different Hazard Ratio |
| EORTC prognostic index for PFS | 2009 | Francart (9) | 523 | PS >0, Stage IV, non-epithelial: ↓PFS | Age, histotype, stage, PS, hgb, WBC |
| Lab/Clinic surgical series of EPP, PD, biopsy | 2009 | Yan (10) | 456 | Young age, pleural effusion, epithelial, EPP, PET scan, adjuvant therapy: ↑survival |
Epithelial and EPP: ↑survival |
| Clinical/Laboratory: Turkey | 2008 | Gonlugur (11) | 71 | Pleural fluid glucose levels, the ratio of pleural fluid to serum LDH >1.0, and total leukocyte count predict OS |
None of the factors were predictive |
| Clinical | 2007 | Flores (12) | 945 | Histology, gender, smoking, asbestos exposure, laterality, surgical resection by EPP or PD, American Joint Committee on Cancer stage, and symptoms | Surgical resection, non smokers, female, no pain, epithelial, left side: ↑survival |
| Clinical | 2005 | Steele (13) | 145 | EORTC prognostic Index: PS, non-epithelial, male, low hgb, high platelet count, high WBC, high LDH: ↓survival | PS, WBC, hgb, uncertain diagnosis, sarcomatoid: ↓survival |
| Clinical | 2004 | Neumann (14) | 155 | Epithelial, young age, female gender: ↑survival |
Epithelial, young age, female gender: ↑survival |
| EORTC and CALGB prognostic indices | 2000 | Edwards (5) | 142 | Male sex, older age, weight loss, chest pain, poor performance status, low hgb, leukocytosis, thrombocytosis, and non-epithelial cell type: ↓survival | Cell type, hgb, white cell count, performance status, and sex |
| Clinical | 1998 | Herndon (15) | 337 | CALGB prognostic Index: PS, chest pain, dyspnea, PLT >400,000/uL, weight loss, serum LDH level >500 IU/L, pleural involvement, low hgb level, high WBC count, and increasing age over 75 years | Pleural involvement, LDH > 500 IU/L, poor PS, chest pain, PLT >400,000, nonepithelial histology, and increasing age older than 75 years |