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. Author manuscript; available in PMC: 2013 Aug 13.
Published in final edited form as: J Am Coll Cardiol. 2011 May 27;58(1):73–82. doi: 10.1016/j.jacc.2010.12.044

Figure 6. SS-31 reduces Ang-induced upregulation of NOX4, activation of p38 MAPK and apoptosis.

Figure 6

(A) NADPH oxidase-4 (NOX4) protein was significantly increased after 4 weeks of Ang or by Gαq overexpression, and this was significantly attenuated by SS-31. (B) Ang for 4 weeks substantially induced apoptosis, as shown by increases cleaved caspase 3 message, and this was significantly attenuated by SS-31. (C) Phosphorylation of p38 MAP kinase was significantly increased after Ang, but was substantially lower in SS-31 treated hearts (upper panel). Protein levels of p38 MAP kinase also increased after Ang, n=3–6.