Skip to main content
. Author manuscript; available in PMC: 2013 Aug 13.
Published in final edited form as: J Med Chem. 2010 Sep 23;53(18):6730–6746. doi: 10.1021/jm100898v

Scheme 1a.

Scheme 1a

aReagents: (a) Boc2O, MeOH, 0 °C; (b) Benzyl chloroformate, Et3N, CH2Cl2, 0 °C → room temperature; (c) (PCy3)2Cl2Ru=CHPh, CH2Cl2, room temperature; (d) (i) NBS, DMSO, H2O, room temperature, (ii) NaOH, MeOH, 0 °C → room temperature.