Scheme 5a.
aReagents: (a) NaN3, 1,4-dioxane, H2O, 100 °C; (b) (i) Trimethylsilylacetylene, toluene, 110 °C, (ii) TBAF (1M in THF), THF, room temperature; (c) 36% aq. HCl, MeOH; (d) Formaldehyde, 9-DAA, 1,4-dioxane, H2O, room temperature.
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