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. Author manuscript; available in PMC: 2013 Aug 13.
Published in final edited form as: J Med Chem. 2010 Sep 23;53(18):6730–6746. doi: 10.1021/jm100898v

Scheme 6a.

Scheme 6a

aReagents: (a) TBAF (1M in THF), THF, room temperature; (b) Benzyl azide, sodium ascorbate, CuSO4, t-BuOH, H2O, room temperature; (c) 36% aq. HCl, MeOH, room temperature; (d) Formaldehyde, 9-DAA, 1,4-dioxane, H2O, room temperature.