Skip to main content
. Author manuscript; available in PMC: 2013 Aug 13.
Published in final edited form as: Biomaterials. 2010 Oct 15;32(3):808–818. doi: 10.1016/j.biomaterials.2010.09.051

Figure 4. Inflammatory responses elicited by different scaffold groups at 70 d post-implantation.

Figure 4

Photomicrographs of gross [A–C] and magnified [A1–C1] regenerated tissue area in augmented bladders following H&E staining. Magnified areas denoted by hashed boxes in [A–C]. [A1] Minimal acute inflammatory reaction elicited by silk matrix denoted by the presence of disperse eosinophil granulocytes (orange arrow). Focal area of mononuclear cell scaffold digestion (red arrow). [B1] Mild chronic inflammatory reaction exemplified by mobilized mononuclear cells in response to SIS implant. [C1] Severe chronic inflammatory reaction elicited by PGA matrix denoted by the presence of multi-nuclear giant cells (blue arrow) as well as foreign body encapsulation of scaffold remnants (black arrow). (*) denotes scaffold fragments. For [A–C] scale bar = 200 µm. For [A1–C1] scale bar = 50 µm.