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. Author manuscript; available in PMC: 2013 Aug 13.

Published in final edited form as: Hum Pathol. 2012 Oct 17;44(4):612–622. doi: 10.1016/j.humpath.2012.07.009

Fig. 1 — Hematoxylin and eosin stained photomicrographs of plasmacytoid urothelial carcinoma are shown in panels A, C, D, E, F. Muscularis propria invasion is shown in C and lymphovascular invasion in F. (×100 and ×400, respectively). B reveals plasmacytoid urothelial carcinoma immunohistochemical positivity for CK8/18 (×200). Representative immunohistochemical staining for PTEN, mTOR pathway members, c-myc, and p27 in tumor cells are illustrated in 1G-1L (×400). G illustrates loss of PTEN staining. Positive PTEN staining in endothelial cells is used as an internal control. H reveals nuclear and cytoplasmic staining for phos-AKT. Cytoplasmic staining for phos-mTOR and phos-S6 is shown in I and J respectively. K and L depict nuclear staining for c-myc and p27, respectively.

Fig. 1 — Hematoxylin and eosin stained photomicrographs of plasmacytoid urothelial carcinoma are shown in panels A, C, D, E, F. Muscularis propria invasion is shown in C and lymphovascular invasion in F. (×100 and ×400, respectively). B reveals plasmacytoid urothelial carcinoma immunohistochemical positivity for CK8/18 (×200). Representative immunohistochemical staining for PTEN, mTOR pathway members, c-myc, and p27 in tumor cells are illustrated in 1G-1L (×400). G illustrates loss of PTEN staining. Positive PTEN staining in endothelial cells is used as an internal control. H reveals nuclear and cytoplasmic staining for phos-AKT. Cytoplasmic staining for phos-mTOR and phos-S6 is shown in I and J respectively. K and L depict nuclear staining for c-myc and p27, respectively.