Table 4.
Associations between biomarkers expression and relevant clinico-pathological characteristics
| PTEN |
Phos-AKT |
Phos-mTOR | Phos-S6 | c-myc | p27 | |||
|---|---|---|---|---|---|---|---|---|
| Loss a (%) |
H Score | Cytoplasmic | Nuclear | |||||
| Gender | ||||||||
| Male | 3/15 (20) | 100 (13–174) | 217 (67–295) | 203 (0–277) | 247 (97–285) | 263 (164–298) | 6 (0–223) | 28 (0–225) |
| Female | 2/3 (67) | 97 (67–131) | 246 (175–268) | 64 (59–185) | 156 (150–238) | 203 (197–251) | 25 (6–44) | 87 (0–175) |
| P value | .172 | .983 | .817 | .301 | .171 | .138 | .792 | .985 |
| pT stage | ||||||||
| pT1 | 2/5 (40) | 100 (13–157) | 200 (67–230) | 26 (0–217) | 243 (97–270) | 276 (264–291) | 5 (0–154) | 26 (0–225) |
| pT2 | 0/6 (0) | 120 (39–174) | 237 (68–280) | 217 (136–240) | 246 (191–275) | 235 (174–282) | 6 (0–187) | 50 (0–175) |
| pT3 | 3/5 (60) | 97 (67–114) | 268 (175–295) | 192 (59–277) | 170 (150–285) | 238 (164–298) | 77 (0–223) | 1 (0–107) |
| pT4 | 0/2 (0) | 66 (33–99) | 248 (246–250) | 212 (189–236) | 248 (240–256) | 253 (244–263) | 28 (0–57) | 134 (48–221) |
| P value | .108 | .417 | .285 | .051 | .598 | .086 | .772 | .520 |
| pT stage groups: | ||||||||
| Muscle invasive | ||||||||
| No (pT1) | 2/5 (40) | 100 (13–157) | 200 (67–230) | 26 (0–217) | 243 (97–270) | 276 (264–291) | 5 (0–154) | 26 (0–225) |
| Yes (pT2+) | 3/13 (23) | 99 (33–174) | 246 (68–295) | 215 (59–277) | 238 (150–285) | 244 (164–298) | 8 (0–223) | 40 (0–221) |
| P value | .583 | .616 | .068 | .007 * | .831 | .009 * | .806 | .700 |
| Organ confined | ||||||||
| Yes (bpT3) | 2/11 (18) | 113 (13–174) | 203 (67–280) | 160 (0–240) | 246 (97–275) | 264 (174–291) | 5 (0–187) | 28 (0–225) |
| No (≥pT3) | 3/7 (43) | 97 (33–114) | 250 (175–295) | 192 (59–277) | 195 (150–285) | 244 (164–298) | 50 (0–223) | 25 (0–221) |
| P value | .326 | .296 | .125 | .260 | .592 | .261 | .467 | .949 |
| Lymph node metastasis | ||||||||
| No (pN0) | 2/4 (50) | 98.5 (67–107) | 276 (200–295) | 159 (64–277) | 175 (148–285) | 271 (164–298) | 24 (0–223) | 53.50 (0–225) |
| Yes (NpN0) | 1/2 (50) | 90.50 (67–114) | 177 (175–179) | 148 (59–238) | 160 (150–170) | 217 (197–238) | 110 (110–110) | 3 (3–3) |
| P value | 1.000 | .814 | .064 | .643 | .643 | .355 | .480 | 1.000 |
| Visceral metastasis | ||||||||
| No | 3/13 (23) | 113 (13–174) | 228 (68–284) | 215 (0–240) | 240 (150–275) | 247 (164–290) | 11 (0–223) | 32 (0–175) |
| Yes | 1/2 (50) | 98 (97–99) | 246 (132–268) | 64 (53–189) | 231 (156–256) | 251 (244–271) | 44 (5–57) | 26 (0–221) |
| P value | .476 | .838 | .916 | .230 | .611 | .611 | 1.000 | 1.000 |
*
Statistically significant.
a
Lymph node and visceral metastasis status was available in only 3 and 4 of the 5 cases with PTEN loss, respectively.