Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
CTLA-4 limits autoantigen-specific T cells at multiple checkpoints. Self-antigen-specific T cells that escape negative selection must either express CTLA-4 themselves or become subject to peripheral control by Treg that also depend on CTLA-4 for their function. As well as restraining activation events in the lymph node, CTLA-4 also prevents T cell infiltration, expansion and survival at the level of the target tissue.
