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. Author manuscript; available in PMC: 2013 Aug 13.

Published in final edited form as: Brain Res. 2009 Jun 25;1287:84–103. doi: 10.1016/j.brainres.2009.06.061

Fig. 4.1 — CCA deactivation network for acupuncture and tactile stimulation, Reference voxels are circled in red, and correlations are circled in green. p < 0.001

a) postC_BA31, right. Figure A. Acupuncture: Ref. voxel (2, −53, 36). There is extensive coherent deactivation bilaterally in the FP, pregC (l), OFC, subgC, SG25 (2) of the MPFC, the PCN, postC_BA31, 23v, RSC (3) of the MPC, the Amy, Hpc, PHpc (4) of the MTL and the TP (5). Figure B. Tactile Stimulation: Ref. voxel (3, −63, 31) Correlation regions overlap with those in acupuncture, but markedly weaker and more limited in extent.

b) PregC, right. Figure A. Acupuncture: Ref. voxel (5, 34, 9) Moderate correlations with BA10 (1), VMPFC, SG25 (2); PCN, BA 31(3), RSC (4) and MTL (5) were found. Figure B. Tactile Stimulation: Ref. vox. (5, 34, −2) A similar spatial distribution but much weaker correlation than in acupuncture was found. There is insignificant correlation within pregC region and FP in midlevel MPFC; stronger correlation is found with VMPFC and subgenual areas in ventral route.

c) SG25, right. Figure A. Acupuncture: Ref. voxel: (5, 17, −13) Strong correlations are found with MPFC, more extensive in the dorsal (1) than in the ventral division (2) Also strong correlations are found with PMPC (3), MTL (4), and TP (5). Figure B. Tactile Stimulation: Ref. voxel (5, 14, −12) Correlations are seen with similar regions but weaker than in acupuncture. SG25 shows the strongest functional connectivity among the regions tested for the deactivation network in tactile stimulation.

d) Hpc, right. Figure A. Acupuncture: Ref. voxel (25, −11, −16). Correlations with MPFC (1), MPC (2) and other TL structures (3) are more limited in extent than with the use of other reference regions from the MPFC or MPC. Figure B. Tactile stimulation: Ref. voxel: (23, −10, −19) Correlations are found in similar regions as in acupuncture, but markedly reduced in extent with only focal correlation in MPC.

e) Amy, right. Figure A. Acupuncture: Ref. voxel (20, 2, −16). Correlations are seen with the FP (1), VMPFC (2), PCN/postC_BA31 of the MPC (3), RSC (4), Hpc/PHpc (5). Figure B. Tactile Stimulation: No significant signal change or regional correlations were found.

f) Hypothalamus, right. Figure A. Acupuncture: Ref. voxel (3, −1, −10) Correlations are seen with the FP, pregC (1), PCN, PCC (2) subgC, VMPFC, SG25 (3), Amy, Hpc, PHpc, TP (4) Figure B. Tactile Stimulation: Ref voxel (3, −1, −10) No significant signal change or regional correlations were found.

Fig. 4.1 — CCA deactivation network for acupuncture and tactile stimulation, Reference voxels are circled in red, and correlations are circled in green. p < 0.001

a) postC_BA31, right. Figure A. Acupuncture: Ref. voxel (2, −53, 36). There is extensive coherent deactivation bilaterally in the FP, pregC (l), OFC, subgC, SG25 (2) of the MPFC, the PCN, postC_BA31, 23v, RSC (3) of the MPC, the Amy, Hpc, PHpc (4) of the MTL and the TP (5). Figure B. Tactile Stimulation: Ref. voxel (3, −63, 31) Correlation regions overlap with those in acupuncture, but markedly weaker and more limited in extent.

b) PregC, right. Figure A. Acupuncture: Ref. voxel (5, 34, 9) Moderate correlations with BA10 (1), VMPFC, SG25 (2); PCN, BA 31(3), RSC (4) and MTL (5) were found. Figure B. Tactile Stimulation: Ref. vox. (5, 34, −2) A similar spatial distribution but much weaker correlation than in acupuncture was found. There is insignificant correlation within pregC region and FP in midlevel MPFC; stronger correlation is found with VMPFC and subgenual areas in ventral route.

c) SG25, right. Figure A. Acupuncture: Ref. voxel: (5, 17, −13) Strong correlations are found with MPFC, more extensive in the dorsal (1) than in the ventral division (2) Also strong correlations are found with PMPC (3), MTL (4), and TP (5). Figure B. Tactile Stimulation: Ref. voxel (5, 14, −12) Correlations are seen with similar regions but weaker than in acupuncture. SG25 shows the strongest functional connectivity among the regions tested for the deactivation network in tactile stimulation.

d) Hpc, right. Figure A. Acupuncture: Ref. voxel (25, −11, −16). Correlations with MPFC (1), MPC (2) and other TL structures (3) are more limited in extent than with the use of other reference regions from the MPFC or MPC. Figure B. Tactile stimulation: Ref. voxel: (23, −10, −19) Correlations are found in similar regions as in acupuncture, but markedly reduced in extent with only focal correlation in MPC.

e) Amy, right. Figure A. Acupuncture: Ref. voxel (20, 2, −16). Correlations are seen with the FP (1), VMPFC (2), PCN/postC_BA31 of the MPC (3), RSC (4), Hpc/PHpc (5). Figure B. Tactile Stimulation: No significant signal change or regional correlations were found.

f) Hypothalamus, right. Figure A. Acupuncture: Ref. voxel (3, −1, −10) Correlations are seen with the FP, pregC (1), PCN, PCC (2) subgC, VMPFC, SG25 (3), Amy, Hpc, PHpc, TP (4) Figure B. Tactile Stimulation: Ref voxel (3, −1, −10) No significant signal change or regional correlations were found.