Table 2.

The BOLD fMRI response in deqi (52 runs in 37 subjects) was compared with deqi plus sharp pain (52 runs in 29 subjects) during acupuncture at right LI4, ST36, LV3, using a voxel by voxel two sample t-test. In the deactivation network , the presence of pain attenuated the signal decrease of most structures (thresholded at p < 0.05). The hypothalamus, left amygdala, cerebellar vermis became activated instead (Fig A). In the activation network, the somatosensory cortex signal increase was enhanced while activation of the right anterior insula and divisions of the cingulate cortex was attenuated on by pain (Fig B). t* is the value taken from the voxel with maximal signal change. Numbers in blue = signal decrease, red = increase.

			Deqi					Mixed					t-test
					%Sig Δ					%Sig Δ			%Sig Δ
Brain Structure	Side/Area		x	y	z	t*	%	x	y	z	t*	%	t	p <
A. Deactivation Network
Posterior cingulate/	L	BA31/7m	−2	−53	38	−20.2	−0.14	−2	−53	33	−4.8	−0.1	3.19	0.002
Precunious	R		3	−55	35	−20.8	−0.14	3	−53	33	−6.1	−0.13	3.32	0.001
Pregenual cingulate/	L	BA32/10	−3	43	2	−9.5	−0.08	−2	46	2	−7.3	−0.12	3.2	0.002
Frontal pole	R		5	37	8	−11.3	−0.08	3	46	2	−8	−0.12	3.29	0.001
Subgenual area	L	SG25	−3	20	−12	−25.6	−0.52	−2	11	−9	−19	−0.63	2.19	0.032
	R		4	18	−12	−35.5	−0.51	4	14	−10	−15.6	−0.42	2.14	0.034
Orbitofrontal cortex	L	BA11	−3	40	−18	−13	−0.16	nil					2.05	0.044
	R		5	52	−21	−20.4	−0.54	nil					2.31	0.004
Temporal pole	L	BA38	−28	19	−32	−26	−0.34	−32	18	−32	−7.6	−0.15	3.31	0.001
	R		35	19	−33	−25.8	−0.32	64	20	−30	−18.7	−0.3	3.19	0.002
Amygdala	L	BA34	−21	−6	−20	−14.3	−0.9	−25	5	−12	4.8	0.12	3.91	0.001
	R		22	−8	−12	−13.6	−0.08	17	5	−15	−7	−0.12	2.63	(0.010)
Hippocampus	L		−18	−11	−15	−12.7	−0.08	nil					3.63	0.001
	R		18	−11	−14	−12.7	−0.11	20	−16	−12	−5	−0.1	3.35	0.001
Parahippocampus	L	BA28/36	−23	−11	−22	−7.9	−0.07	nil					2.96	0.004
	R		19	−7	−25	−11.6	−0.12	25	−22	−21	5.9	0.24	2.52	0.014
Hypothalamus	L		−1	−2	−8	−20.2	−0.2	−1	−4	−7	5.9	0.12	3.88	0.001
	R		2	−2	−8	−18.6	−0.2	2	−6	−6	5.8	0.14	3.27	0.002
Cerebellar vermis	lobule VII		−1	−79	−30	−7.9	−0.16	−1	−71	−21	11	0.15	3.52	0.001
	lobule VIII		−1	−65	−37	−6.5	−0.12	−1	−63	−27	9.3	0.14	3.66	0.001
B. Activation Network
SII, operculum	L	BA43	−61	−12	20	15.4	0.16	−62	−13	17	17.09	0.33	3.73	0.001
	R		59	−12	20	6.7	0.05	55	−6	11	7.4	0.14	ns
SII, inferior parietal	L	BA40	−59	−21	22	19.8	0.16	−64	−25	20	15.7	0.42	5.4	0.001
	R		54	−21	25	13.3	0.1	55	−25	26	13	0.16	3.51	0.001
Ant middle cingulate/DMPFC	L	BA32/10	nil					−2	22	41	11	0.15	3.91	0.001
	R		4	27	37	7.8	0.07	1	31	34	10	0.15	5.93	0.001
Ant middle cingulate	L	BA24	−3	14	32	7.4	0.08	−3	19	27	6.9	0.1	2.91	0.005
	R		3	11	34	6.2	0.07	2	18	31	7.6	0.15	3.95	0.001