Table 2. The results of Kyoto Encyclopedia Genes and Genomes (KEGG) Pathway assay.
| PathwayID | Definition | Fisher-P value | Enrichment Score |
|---|---|---|---|
| mmu04724 | Glutamatergic synapse | 0.00031325 | 3.504109 |
| mmu05200 | Pathways in cancer | 0.000364143 | 3.438728 |
| mmu04360 | Axon guidance | 0.000371743 | 3.429757 |
| mmu04070 | Phosphatidylinositol signaling system | 0.001969461 | 2.705653 |
| mmu00562 | Inositol phosphate metabolism | 0.002646183 | 2.57738 |
| mmu04666 | Fc gamma R-mediated phagocytosis | 0.004516641 | 2.345184 |
| mmu05100 | Bacterial invasion of epithelial cells | 0.006824978 | 2.165899 |
| mmu04722 | Neurotrophin signaling pathway | 0.006869456 | 2.163078 |
| mmu04350 | TGF-beta signaling pathway | 0.01427558 | 1.845406 |
| mmu05014 | Amyotrophic lateral sclerosis (ALS) | 0.01455702 | 1.836928 |
| mmu04510 | Focal adhesion | 0.0197738 | 1.70391 |
| mmu04721 | Synaptic vesicle cycle | 0.02158243 | 1.6659 |
| mmu04141 | Protein processing in endoplasmic reticulum | 0.02556368 | 1.592377 |
| mmu04530 | Tight junction | 0.02830684 | 1.548109 |
| mmu04810 | Regulation of actin cytoskeleton | 0.03108982 | 1.507382 |
| mmu05212 | Pancreatic cancer | 0.03178773 | 1.497741 |
| mmu05211 | Renal cell carcinoma | 0.03323187 | 1.478445 |
| mmu04725 | Cholinergic synapse | 0.04785029 | 1.320115 |
| mmu00564 | Glycerophospholipid metabolism | 0.04976589 | 1.303068 |
| mmu00190 | Oxidative phosphorylation | 0.02234092 | 1.650899 |
Kyoto Encyclopedia Genes and Genomes (KEGG) pathway analysis was performed to identify possible enrichment of genes with specific biologic themes on the basis of identify possible enrichment of genes with specific biologic themes on the basis of biologic process, cellular component, and molecular function. We identified the significant KEGG pathways using the DAVID Bioinformatics Resources. Fisher’s exact test was used to determine the enrichment in categories with target genes in the DAVID bioinformatics resource.