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Genistein induces G2/M cell cycle arrest in both HCT-116 p53+/+ and p53−/− cells via a p53-dependent pathway. Genistein arrested more HCT-116 p53+/+ cells in the G2/M phase than in the p53−/− cells at concentrations (25 and 50 μM) (33.1 vs 25.8%, 45.6 vs 28%).
