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Schematic diagram of miRNA arm selection. Pri-miRNA is transcribed by RNA polymerase II and processed into pre-miRNA by Drosha/DGCR8 in the nucleus. Then pre-miRNA is processed into a duplex form of mRNA that is unwound during RISC assembly in the cytoplasm. Selection of the miRNA* sequence is determined by target transcript abundances. When miRNA* target transcripts are sufficiently abundant the miRNA* sequence is stabilized and acts on target transcripts in the same manner as miRNA.
