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. 2013 Jun 26;14(7):13307–13328. doi: 10.3390/ijms140713307

Figure 2.

Figure 2

Schematic of proposed origin of TE-based miRNAs. When two related but not identical LINE1elements insert themselves near each other, but on opposite strands of the DNA (in blue), they can create a precursor miRNA containing an imperfect stem-loop upon transcription (red line). The pre-miRNA is shown above the arrow and transcription is indicated from the positive strand LINE1. The stem is potentially recognized and processed by the endogenous RNAi machinery. The pre-miRNA stem-loop depicted is representational. Modified from [26].