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. 2013 Jul 2;14(7):13748–13762. doi: 10.3390/ijms140713748

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Dual-color fluorescence in situ hybridization (FISH) validates amplification of the KRAS or MAPK1 gene in type II ovarian carcinoma. (A) FISH analysis of KRAS showed a homogeneously stained region in a tumor with gene amplification. White arrows indicated amplification of KRAS gene; (B) FISH analysis of MAPK1 showed a homogeneously stained region in a tumor with gene amplification. White arrows indicated amplification of MAPK1 gene; (C) Intense immunoreactivity toward p-ERK was present in both the nuclei and cytoplasm of carcinoma cells; (D) This sample shows negative case of staining for p-ERK.

Dual-color fluorescence in situ hybridization (FISH) validates amplification of the KRAS or MAPK1 gene in type II ovarian carcinoma. (A) FISH analysis of KRAS showed a homogeneously stained region in a tumor with gene amplification. White arrows indicated amplification of KRAS gene; (B) FISH analysis of MAPK1 showed a homogeneously stained region in a tumor with gene amplification. White arrows indicated amplification of MAPK1 gene; (C) Intense immunoreactivity toward p-ERK was present in both the nuclei and cytoplasm of carcinoma cells; (D) This sample shows negative case of staining for p-ERK.