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Clusters of miRNAs specifically expressed in embryonic stem cells (ESCs). (a) Schematic representations of the two ESC-specific miRNA clusters in mouse and human. miRNAs with the AAGUGC seed sequence within each cluster are underlined. The miR-302/367 cluster is highly conserved in mammals, whereas the other cluster is less conserved; (b) The two clusters are differentially expressed in ESCs during the conversion between the naïve and primed states of pluripotency.
