Table 2. Functional annotation clusters of genes induced in C. albicans-stimulated RPM.
| Annotation Clusters | Official Symbol |
|---|---|
| Apoptosis | Bcl2l11, Cflar, Cd24a, Chac1, Ddit4, Egin3, Epha2, Rybp, Traf1, Traf5, Ahr, F2r, Csrnp1, Fem1b, Gzmb, Gadd45b, Gadd45g, Id1, Il6, Jmjd6, Malt1, Myc, Niacr1, Nfκb1, Nr4a2, Osm, Phlda1, Bnip3, Blcap, Ppp1r15a, Srgn, Siah2, Mcl1, Trib3, Trim69, Tnf, Tnfrsf12a, Tnfaip3, Unc5b, Zc3h12a |
| Cytokines, Response to wounding, and Inflammatory response | Areg, Cd24a, Kdm6b, Bmp2, Bmp6, Ccl2, Ccl3, Ccl4, Ccl7, Ccr1, Cxcl1, Cxcl2, Cxcl3, Csf2, Csf3, F2r, F3,Gdf15, Gja1, Hbegf, Id3, Il1a, Il1b, Il1f6, Il10, Il23a, Il6, Nfkbid, Olr1, Osm, Plaur, Plek, Procr, Proz, Slc7a2, Sphk1, Tnf, Tnfsf9 |
| Regulation of phosphorylation and protein kinase activity | Cd24a, Adora2a, Bmp2, F2r, Cdkn1a, Cish, Dgkg, Dusp16, Edn1, Ereg, Gadd45b, Gadd45g, Il1b, Il6, Lrp8, Laper1, Nrg1, Osm, Reln, Spag9, Sphk, Spry2, Socs3, Trib3, Tnf |
| Cell motion | Cd24a, Epha4, Alcam, Ccr1, Cxcl2, Cxcl3, Egr2, Gja1, Hbegf, Il1b, Lrp8, Nrg1, Nr4a2, Plau, Pdpn, Pvr, Reln, Runx3, Zfand5, Tes, Tnf, Tnfrsf12a, Vegfa |
| Vascular development | Epha2, Junb, Smad7, Edn1, Efnb2, Ereg, Gja1, Hbegf, Id1, Itgav, Il1b, Jmjd6, Pdpn, Prok2, Zfand5, Sphk1, Socs3, Tgm2, Tnfrsf12a, Vegfa, Zc3h12a, Zfp36l1 |
| Regulation of cytokine production | Cd24a, Cd83, Adora2a, Adora2b, F2r, Edn1, Ereg, Fst, Inhbb, Irf4, Il1a, Il1b, Il10, Il6, Nfκb1, Prok2, Rel, Srgn, Sphk1, Tnf |
| MAP kinase phosphatase activity | Dusp1, Dusp2, Dusp4, Dusp8, Dusp10, Dusp14, Dusp16 |
| Regulation of transcription from RNA polymerase II promoter | Eaf1, Kdm6b, Mxi1, Pou3f1, Rybp, Skil, Atf4, Ahr, Bmp2, Csrnp1, Egr1, Egr2, Fosl1, Hes1, Inhba, Id1, Id2, Id3, Irf4, Il6, Jarid2, Med13, Myc, Nfκb1, Nufip1, Nr4a1, Nr4a2, Nr4a3, Osm, Plagl1, Pbx1, Sap30, Tnf, Vegfa |
| Growth factor activity | Areg, Bmp2, Bmp6, Cxcl1, Csf2, Csf3, Ereg, Gdf15, Hbegf, Inhba, Inhbb, Il1b, Il6, Vegfa |
Genes expressed at higher levels (427 genes, ≥4-fold, <0.05) in C. albicans-stimulated cPLA2α+/+ RPM were analyzed using DAVID bioinformatics resource.