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. Author manuscript; available in PMC: 2013 Aug 13.
Published in final edited form as: Tex Dent J. 2010 Jul;127(7):651–661.

Table 1.

Biomarker Discovery and Strategies for Saliva/Oral Fluid Diagnostics

Potential Biomarkers Strategies of Saliva Diagnostics
Electrolytes: Na+, K+, HCO3−, Ca2+, P043−
Proteins (Proteome)
 Salivary proteins
 Salivary serum components
Transcriptome mRNA and miRNA profiles
DNA: mammalian cells (epithelial and inflammatory cells and microorganisms (e.g., bacteria, fungi, viruses)		 Multiplex:
 Multiple samples
 Multiple analyses
High Sensitivity and Specificity
Miniaturization:
 Portable
 Nanotechnologies: Lab-on-a-Chip (LOC)
Automated and Self-powered
 Point of Care (POC)